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This course is devoted to the study of the physiological process of disease and the body’s response to this process. It is the goal of the course to present broad physiological principles that advanced nurse practitioners can apply to their clinical experiences. Specific diseases will be used to exemplify pathophysiological concepts, and treatment is examined at the molecular level as response to the pathophysiology. The course investigates exogenous causes of diseases emphasizing infection, inflammation, and the immune response as well as endogenous diseases of the nervous, endocrine, cardiovascular, hepatic, pulmonary, and renal systems.