NURS 4415: Research and Evidence-Based Practice

From Kim Louie - Lumen Learning

The following guides provide glossaries of research terminology with definitions:

• Glossary of Research Terms (University of Southern California)
• Glossary of Key Terms (Colorado State University)
• Glossary of Research Terms (University of Virginia School of Medicine)

In Evidence-Based Practice, the formulation of a good clinical question is crucial to your research. The PICO model can help with formulating well-built clinical questions.

P = Patient, Problem, or Population
How would you describe a group of patients similar to you? What are the most important characteristics of the patient?

I = Intervention, Prognostic Factor, or Exposure
What main intervention, prognostic factor, or exposure are you considering? What do you want to do with this patient?

C = Comparison
What is the main alternative to compare with the intervention?

O = Outcome
What are you trying to accomplish, measure, improve, or affect?

For additional help with using PICO to form clinical questions, check out these resources:

• Evidence-Based Practice: PICO (Duke University)
• Evidence Based Medicine (University of Illinois Chicago)
• Types of Clinical Questions (Georgetown University)
• PICO - Clinical Question (University of Wisconsin-Madison)

Ethical considerations in research are critical. Ethics are the norms or standards for conduct that distinguish between right and wrong, and they help determine the difference between acceptable and unacceptable behaviors. Ethical considerations are important in research because maintaining ethical standards:

• helps prevent against the fabrication or falsifying of data
• promotes the pursuit of knowledge and truth
• encourages an environment of trust, accountability, and mutual respect among researchers in regards to data sharing, co-authorship, copyright guidelines, confidentiality, and other issues
• reassures the public that researchers are following appropriate guidelines in regards to human rights, animal welfare, compliance with the law, conflicts of interest, safety, and health standards
• positively impacts the integrity of the research project and can help secure funding

Many professional associations and agencies have adopted codes and policies that outline ethical behavior and guide researchers. These codes address issues such as honesty, objectivity, respect for intellectual property, social responsibility, confidentiality, non-discrimination, and others. One example of such ethics guidelines is Ethical Issues in Patient Safety Research from the World Health Organization. 

One of the most important ethical considerations in research is the use of human subjects. Most institutions and organizations, including Clarion University, have an Institutional Review Board (IRB). An IRB is a panel of individuals who help to ensure the safety of human subjects in research and who assist in making sure that human rights are not violated. They review research proposals, specifically the methodology, to assure ethical practices are being followed. An IRB also helps to protect the institution and researchers against potential legal implications from any behavior that may be deemed unethical.

Adapted from Ethical Considerations (CIRT)

The Code of Ethics for Nurses with Interpretive Statements (The Code) was developed as a guide for carrying out nursing responsibilities in a manner consistent with quality in nursing care and the ethical obligations of the profession.

You can view the Code of Ethics on the American Nurses Association website or using this PDF from Rutgers University.



The following resources provide information and guidelines for the use of human subjects during research:

• Office for Human Research Protections
• Human Subject Regulations Decision Charts
• Human Subjects in Research: Things to Consider (National Institute of Mental Health)
• Research Using Human Subjects (National Institute of Allergy and Infectious Diseases)
• Informed Consent (American Medical Association)